"fibrodysplasia ossificans progressiva" meaning in All languages combined

See fibrodysplasia ossificans progressiva on Wiktionary

Noun [English]

IPA: /ˌfaɪbɹəʊdɪsˈpleɪzɪə ɒˈsɪfɪkɑːnz pɹəˈɡɹɛsɪvə/ [Received-Pronunciation], /-ˈpleɪʒə-/ [Received-Pronunciation], /ˌfaɪbɹoʊdɪsˈpleɪʒ(i)ə ɒˈsɪfɪkænz pɹəˈɡɹɛsɪvə/ [General-American], /-ˈpleɪziə-/ [General-American], /-pɹoʊ-/ [General-American] Audio: En-us-fibrodysplasia ossificans progressiva.oga [General-American]
Etymology: PIE word *h₃ésth₁ From English fibrodysplasia, and borrowed from New Latin ossificans + Latin prōgressīvā, literally “abnormal development of fibrous tissue with ossification that is progressive”: * Fibrodysplasia is derived from fibro- (prefix meaning ‘fibre; fibrous’) (from Latin fibra (“fibre; filament”), ultimately from Proto-Indo-European *bʰeyd- (“to split”)) + dysplasia (“abnormal development of cells or tissue”) (from dys- (prefix meaning ‘abnormal; disease’) + -plasia (suffix meaning ‘formation; growth’)). * Ossificans is from Latin ossīs (a plural form of ossum (“bone”), ultimately from Proto-Indo-European *h₃ésth₁ (“bone”)) + -ficāns (the present active participle of -ficō (suffix forming chiefly causative or factitive verbs)). * Prōgressīvā is the ablative feminine singular of prōgressīvus (“progressive”), from prōgressus (“advanced, proceeded; developed, progressed”) (the perfect active participle of prōgredior (“to advance, proceed; (figurative) to develop, progress”), from prō- (prefix denoting a forward direction) + gradior (“to step; to walk; to advance”) (ultimately from Proto-Indo-European *gʰredʰ- (“to go; to walk”))) + -īvus (suffix forming adjectives). The disease was originally termed myositis ossificans progressiva in 1868. The use of fibrodysplasia in place of myositis was suggested by K. H. Bauer and W. Bode in 1940, and adopted by the American medical geneticist Victor A. McKusick (1921–2008) in his work Heritable Disorders of Connective Tissue (1956). Etymology templates: {{PIE word|en|h₃ésth₁}} PIE word *h₃ésth₁, {{root|en|ine-pro|*bʰeyd-|*dus-|*dʰeh₁-|*pro-|*gʰredʰ-|*-wós}}, {{bor|en|NL.|ossificans}} New Latin ossificans, {{bor|en|la|prōgressīvā}} Latin prōgressīvā, {{glossary|prefix}} prefix, {{der|en|la|fibra|t=fibre; filament}} Latin fibra (“fibre; filament”), {{der|en|ine-pro|*bʰeyd-|t=to split}} Proto-Indo-European *bʰeyd- (“to split”), {{glossary|suffix}} suffix, {{der|en|la|ossīs}} Latin ossīs, {{glossary|plural}} plural, {{der|en|ine-pro|*h₃ésth₁|t=bone}} Proto-Indo-European *h₃ésth₁ (“bone”), {{glossary|present}} present, {{glossary|active}} active, {{glossary|participle}} participle, {{glossary|causative}} causative, {{glossary|factitive}} factitive, {{glossary|verb}} verb, {{glossary|ablative}} ablative, {{glossary|feminine}} feminine, {{glossary|singular}} singular, {{glossary|perfect}} perfect, {{glossary|active}} active, {{glossary|participle}} participle, {{der|en|ine-pro|*gʰredʰ-|t=to go; to walk}} Proto-Indo-European *gʰredʰ- (“to go; to walk”), {{glossary|adjective}} adjective Head templates: {{en-noun|-|head=fibrodysplasia ossificans progressiva}} fibrodysplasia ossificans progressiva (uncountable)
  1. (medical genetics) A very rare, disabling genetic disorder of the connective tissue in which fibrous tissue (including ligaments, muscles, and tendons) ossifies (“transforms into bone”) when damaged. Wikipedia link: Harry Raymond Eastlack, Julius Springer, Mütter Museum, Theodor von Dusch, Victor A. McKusick Tags: uncountable Categories (topical): Genetic disorders Synonyms: FOP, Münchmeyer disease, myositis ossificans progressiva, stone man syndrome Translations (genetic disorder in which fibrous tissue ossifies when damaged): خلل التنسج الليفي المعظم المترقي (Arabic), fibrodisplasia osifikatzaile progresibo [feminine] (Basque), fibrodisplàsia ossificant progressiva [feminine] (Catalan), 進行性骨化性纖維發育不良 (Chinese Mandarin), 进行性骨化性纤维发育不良 (jìnxíngxìnggǔhuàxìngxiānwéifāyùbùliáng) (Chinese Mandarin), fibrodysplasia ossificans progressiva (Czech), fibrodysplasia ossificans progressiva (Dutch), progresa ostiĝa fibrodisplazio (Esperanto), fibrodysplasia ossificans progressiva (Finnish), Fibrodysplasia ossificans progressiva [feminine] (German), תסמונת FOP (Hebrew), fibrodisplasia ossificante progressiva [feminine] (Italian), 進行性骨化性線維異形成症 (shin kōsei kotsu ka sei sen ī kei seishou) (alt: しんこうせい こつかせい せんいいけいせいしょう) (Japanese), 진행성 골화성 섬유이형성증 (jinhaengseong golhwaseong seomyuihyeongseongjeung) (alt: 進行性骨化性纖維異形成症) (Korean), progresējošā osificējošā fibrodisplāzija (Latvian), fibrodysplasia ossificans progressiva (Limburgish), прогресивна осифирачка фибродисплазија (progresivna osifiračka fibrodisplazija) (Macedonian), ഫൈബ്രോഡിസ്പ്ലാസിയ ഓസിഫിക്കൻസ് പ്രോഗ്രെസ്സിവ (phaibrōḍisplāsiya ōsiphikkaṉsŭ prōgressiva) (Malayalam), فیبرودیسپلازی استخوانیشونده پیشرونده (Persian), postępujące kostniejące zapalenie mięśni [neuter] (Polish), fibrodisplasia ossificante progressiva [feminine] (Portuguese), fibrodisplazie osificantă progresivă [feminine] (Romanian), фибродисплази́я оссифици́рующая прогресси́рующая (fibrodisplazíja ossificírujuščaja progressírujuščaja) [feminine] (Russian), fibrodisplasia osificante progresiva [feminine] (Spanish), fibrodisplazi ossifikans progressiva (Turkish), hội chứng người hoá đá (Vietnamese)
    Sense id: en-fibrodysplasia_ossificans_progressiva-en-noun-Ite3257d Categories (other): English entries with incorrect language header

Alternative forms

Download JSON data for fibrodysplasia ossificans progressiva meaning in All languages combined (13.5kB)

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  "etymology_text": "PIE word\n *h₃ésth₁\nFrom English fibrodysplasia, and borrowed from New Latin ossificans + Latin prōgressīvā, literally “abnormal development of fibrous tissue with ossification that is progressive”:\n* Fibrodysplasia is derived from fibro- (prefix meaning ‘fibre; fibrous’) (from Latin fibra (“fibre; filament”), ultimately from Proto-Indo-European *bʰeyd- (“to split”)) + dysplasia (“abnormal development of cells or tissue”) (from dys- (prefix meaning ‘abnormal; disease’) + -plasia (suffix meaning ‘formation; growth’)).\n* Ossificans is from Latin ossīs (a plural form of ossum (“bone”), ultimately from Proto-Indo-European *h₃ésth₁ (“bone”)) + -ficāns (the present active participle of -ficō (suffix forming chiefly causative or factitive verbs)).\n* Prōgressīvā is the ablative feminine singular of prōgressīvus (“progressive”), from prōgressus (“advanced, proceeded; developed, progressed”) (the perfect active participle of prōgredior (“to advance, proceed; (figurative) to develop, progress”), from prō- (prefix denoting a forward direction) + gradior (“to step; to walk; to advance”) (ultimately from Proto-Indo-European *gʰredʰ- (“to go; to walk”))) + -īvus (suffix forming adjectives).\nThe disease was originally termed myositis ossificans progressiva in 1868. The use of fibrodysplasia in place of myositis was suggested by K. H. Bauer and W. Bode in 1940, and adopted by the American medical geneticist Victor A. McKusick (1921–2008) in his work Heritable Disorders of Connective Tissue (1956).",
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          "ref": "1956, Victor A[lmon] McKusick, “Concluding Comments”, in Heritable Disorders of Connective Tissue, St. Louis, Mo.: The C. V. Mosby Company, →OCLC, pages 194–195",
          "text": "The cardinal manifestations of fibrodysplasia ossificans progressiva are microdactyly and progressive ossification of fascia, [aponeuroses], and other fibrous structures related to muscles.",
          "type": "quotation"
        },
        {
          "ref": "2006 April 23, Eileen M. Shore [et al.], “A Recurrent Mutation in the BMP Type I Receptor ACVR1 Causes Inherited and Sporadic Fibrodysplasia Ossificans Progressiva”, in Nature Genetics, volume 38, New York, N.Y.: Nature Portfolio, published 1 May 2006, →DOI, →ISSN, →OCLC, abstract, page 525",
          "text": "Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. We mapped FOP to chromosome 2q23-24 by linkage analysis and identified an identical heterozygous mutation (617G → A; R206H) in the glycine-serine (GS) activation domain of ACVR1, a BMP type I receptor, in all affected individuals examined.\nThis article announced the discovery of the gene in which a mutation causes the disease.",
          "type": "quotation"
        },
        {
          "ref": "2022 July 7, Alex Pope, “Hemel Hempstead Mother’s Funding Plea for Daughter’s Rare Disease”, in BBC News, archived from the original on 2023-12-11",
          "text": "A mother of a one-year-old girl with an illness that turns muscle into bone has urged the government to do more to help research into rare conditions. Lexi Robins, of Hemel Hempstead has the very rare condition Fibrodysplasia Ossificans Progressiva (FOP).",
          "type": "quotation"
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        "A very rare, disabling genetic disorder of the connective tissue in which fibrous tissue (including ligaments, muscles, and tendons) ossifies (“transforms into bone”) when damaged."
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        [
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          "connective tissue"
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        [
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          "fibrous"
        ],
        [
          "tissue",
          "tissue#Noun"
        ],
        [
          "ligament",
          "ligament"
        ],
        [
          "muscles",
          "muscle#Noun"
        ],
        [
          "tendon",
          "tendon"
        ],
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          "ossifies",
          "ossify#English"
        ],
        [
          "transforms",
          "transform#Verb"
        ],
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          "bone#Noun"
        ],
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          "damaged",
          "damage#Verb"
        ]
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      "qualifier": "medical genetics",
      "raw_glosses": [
        "(medical genetics) A very rare, disabling genetic disorder of the connective tissue in which fibrous tissue (including ligaments, muscles, and tendons) ossifies (“transforms into bone”) when damaged."
      ],
      "synonyms": [
        {
          "word": "FOP"
        },
        {
          "word": "Münchmeyer disease"
        },
        {
          "word": "myositis ossificans progressiva"
        },
        {
          "word": "stone man syndrome"
        }
      ],
      "tags": [
        "uncountable"
      ],
      "translations": [
        {
          "code": "ar",
          "lang": "Arabic",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "خلل التنسج الليفي المعظم المترقي"
        },
        {
          "code": "eu",
          "lang": "Basque",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "feminine"
          ],
          "word": "fibrodisplasia osifikatzaile progresibo"
        },
        {
          "code": "ca",
          "lang": "Catalan",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "feminine"
          ],
          "word": "fibrodisplàsia ossificant progressiva"
        },
        {
          "code": "cmn",
          "lang": "Chinese Mandarin",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "進行性骨化性纖維發育不良"
        },
        {
          "code": "cmn",
          "lang": "Chinese Mandarin",
          "roman": "jìnxíngxìnggǔhuàxìngxiānwéifāyùbùliáng",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "进行性骨化性纤维发育不良"
        },
        {
          "code": "cs",
          "lang": "Czech",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "fibrodysplasia ossificans progressiva"
        },
        {
          "code": "nl",
          "lang": "Dutch",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "fibrodysplasia ossificans progressiva"
        },
        {
          "code": "eo",
          "lang": "Esperanto",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "progresa ostiĝa fibrodisplazio"
        },
        {
          "code": "fi",
          "lang": "Finnish",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "fibrodysplasia ossificans progressiva"
        },
        {
          "code": "fr",
          "lang": "French",
          "note": "fibrodysplasie ossifiante progressive f",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged"
        },
        {
          "code": "de",
          "lang": "German",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "feminine"
          ],
          "word": "Fibrodysplasia ossificans progressiva"
        },
        {
          "code": "he",
          "lang": "Hebrew",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "תסמונת FOP"
        },
        {
          "code": "it",
          "lang": "Italian",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "feminine"
          ],
          "word": "fibrodisplasia ossificante progressiva"
        },
        {
          "alt": "しんこうせい こつかせい せんいいけいせいしょう",
          "code": "ja",
          "lang": "Japanese",
          "roman": "shin kōsei kotsu ka sei sen ī kei seishou",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "進行性骨化性線維異形成症"
        },
        {
          "alt": "進行性骨化性纖維異形成症",
          "code": "ko",
          "lang": "Korean",
          "roman": "jinhaengseong golhwaseong seomyuihyeongseongjeung",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "진행성 골화성 섬유이형성증"
        },
        {
          "code": "lv",
          "lang": "Latvian",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "progresējošā osificējošā fibrodisplāzija"
        },
        {
          "code": "li",
          "lang": "Limburgish",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "fibrodysplasia ossificans progressiva"
        },
        {
          "code": "mk",
          "lang": "Macedonian",
          "roman": "progresivna osifiračka fibrodisplazija",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "прогресивна осифирачка фибродисплазија"
        },
        {
          "code": "ml",
          "lang": "Malayalam",
          "roman": "phaibrōḍisplāsiya ōsiphikkaṉsŭ prōgressiva",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "ഫൈബ്രോഡിസ്പ്ലാസിയ ഓസിഫിക്കൻസ് പ്രോഗ്രെസ്സിവ"
        },
        {
          "code": "fa",
          "lang": "Persian",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "فیبرودیسپلازی استخوانیشونده پیشرونده"
        },
        {
          "code": "pl",
          "lang": "Polish",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "neuter"
          ],
          "word": "postępujące kostniejące zapalenie mięśni"
        },
        {
          "code": "pt",
          "lang": "Portuguese",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "feminine"
          ],
          "word": "fibrodisplasia ossificante progressiva"
        },
        {
          "code": "ro",
          "lang": "Romanian",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "feminine"
          ],
          "word": "fibrodisplazie osificantă progresivă"
        },
        {
          "code": "ru",
          "lang": "Russian",
          "roman": "fibrodisplazíja ossificírujuščaja progressírujuščaja",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "feminine"
          ],
          "word": "фибродисплази́я оссифици́рующая прогресси́рующая"
        },
        {
          "code": "es",
          "lang": "Spanish",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "tags": [
            "feminine"
          ],
          "word": "fibrodisplasia osificante progresiva"
        },
        {
          "code": "tr",
          "lang": "Turkish",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "fibrodisplazi ossifikans progressiva"
        },
        {
          "code": "vi",
          "lang": "Vietnamese",
          "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
          "word": "hội chứng người hoá đá"
        }
      ],
      "wikipedia": [
        "Harry Raymond Eastlack",
        "Julius Springer",
        "Mütter Museum",
        "Theodor von Dusch",
        "Victor A. McKusick"
      ]
    }
  ],
  "sounds": [
    {
      "ipa": "/ˌfaɪbɹəʊdɪsˈpleɪzɪə ɒˈsɪfɪkɑːnz pɹəˈɡɹɛsɪvə/",
      "tags": [
        "Received-Pronunciation"
      ]
    },
    {
      "ipa": "/-ˈpleɪʒə-/",
      "tags": [
        "Received-Pronunciation"
      ]
    },
    {
      "ipa": "/ˌfaɪbɹoʊdɪsˈpleɪʒ(i)ə ɒˈsɪfɪkænz pɹəˈɡɹɛsɪvə/",
      "tags": [
        "General-American"
      ]
    },
    {
      "ipa": "/-ˈpleɪziə-/",
      "tags": [
        "General-American"
      ]
    },
    {
      "ipa": "/-pɹoʊ-/",
      "tags": [
        "General-American"
      ]
    },
    {
      "audio": "En-us-fibrodysplasia ossificans progressiva.oga",
      "mp3_url": "https://upload.wikimedia.org/wikipedia/commons/transcoded/b/b3/En-us-fibrodysplasia_ossificans_progressiva.oga/En-us-fibrodysplasia_ossificans_progressiva.oga.mp3",
      "ogg_url": "https://upload.wikimedia.org/wikipedia/commons/b/b3/En-us-fibrodysplasia_ossificans_progressiva.oga",
      "tags": [
        "General-American"
      ],
      "text": "Audio (GA)"
    }
  ],
  "word": "fibrodysplasia ossificans progressiva"
}
{
  "etymology_templates": [
    {
      "args": {
        "1": "en",
        "2": "h₃ésth₁"
      },
      "expansion": "PIE word\n *h₃ésth₁",
      "name": "PIE word"
    },
    {
      "args": {
        "1": "en",
        "2": "ine-pro",
        "3": "*bʰeyd-",
        "4": "*dus-",
        "5": "*dʰeh₁-",
        "6": "*pro-",
        "7": "*gʰredʰ-",
        "8": "*-wós"
      },
      "expansion": "",
      "name": "root"
    },
    {
      "args": {
        "1": "en",
        "2": "NL.",
        "3": "ossificans"
      },
      "expansion": "New Latin ossificans",
      "name": "bor"
    },
    {
      "args": {
        "1": "en",
        "2": "la",
        "3": "prōgressīvā"
      },
      "expansion": "Latin prōgressīvā",
      "name": "bor"
    },
    {
      "args": {
        "1": "prefix"
      },
      "expansion": "prefix",
      "name": "glossary"
    },
    {
      "args": {
        "1": "en",
        "2": "la",
        "3": "fibra",
        "t": "fibre; filament"
      },
      "expansion": "Latin fibra (“fibre; filament”)",
      "name": "der"
    },
    {
      "args": {
        "1": "en",
        "2": "ine-pro",
        "3": "*bʰeyd-",
        "t": "to split"
      },
      "expansion": "Proto-Indo-European *bʰeyd- (“to split”)",
      "name": "der"
    },
    {
      "args": {
        "1": "suffix"
      },
      "expansion": "suffix",
      "name": "glossary"
    },
    {
      "args": {
        "1": "en",
        "2": "la",
        "3": "ossīs"
      },
      "expansion": "Latin ossīs",
      "name": "der"
    },
    {
      "args": {
        "1": "plural"
      },
      "expansion": "plural",
      "name": "glossary"
    },
    {
      "args": {
        "1": "en",
        "2": "ine-pro",
        "3": "*h₃ésth₁",
        "t": "bone"
      },
      "expansion": "Proto-Indo-European *h₃ésth₁ (“bone”)",
      "name": "der"
    },
    {
      "args": {
        "1": "present"
      },
      "expansion": "present",
      "name": "glossary"
    },
    {
      "args": {
        "1": "active"
      },
      "expansion": "active",
      "name": "glossary"
    },
    {
      "args": {
        "1": "participle"
      },
      "expansion": "participle",
      "name": "glossary"
    },
    {
      "args": {
        "1": "causative"
      },
      "expansion": "causative",
      "name": "glossary"
    },
    {
      "args": {
        "1": "factitive"
      },
      "expansion": "factitive",
      "name": "glossary"
    },
    {
      "args": {
        "1": "verb"
      },
      "expansion": "verb",
      "name": "glossary"
    },
    {
      "args": {
        "1": "ablative"
      },
      "expansion": "ablative",
      "name": "glossary"
    },
    {
      "args": {
        "1": "feminine"
      },
      "expansion": "feminine",
      "name": "glossary"
    },
    {
      "args": {
        "1": "singular"
      },
      "expansion": "singular",
      "name": "glossary"
    },
    {
      "args": {
        "1": "perfect"
      },
      "expansion": "perfect",
      "name": "glossary"
    },
    {
      "args": {
        "1": "active"
      },
      "expansion": "active",
      "name": "glossary"
    },
    {
      "args": {
        "1": "participle"
      },
      "expansion": "participle",
      "name": "glossary"
    },
    {
      "args": {
        "1": "en",
        "2": "ine-pro",
        "3": "*gʰredʰ-",
        "t": "to go; to walk"
      },
      "expansion": "Proto-Indo-European *gʰredʰ- (“to go; to walk”)",
      "name": "der"
    },
    {
      "args": {
        "1": "adjective"
      },
      "expansion": "adjective",
      "name": "glossary"
    }
  ],
  "etymology_text": "PIE word\n *h₃ésth₁\nFrom English fibrodysplasia, and borrowed from New Latin ossificans + Latin prōgressīvā, literally “abnormal development of fibrous tissue with ossification that is progressive”:\n* Fibrodysplasia is derived from fibro- (prefix meaning ‘fibre; fibrous’) (from Latin fibra (“fibre; filament”), ultimately from Proto-Indo-European *bʰeyd- (“to split”)) + dysplasia (“abnormal development of cells or tissue”) (from dys- (prefix meaning ‘abnormal; disease’) + -plasia (suffix meaning ‘formation; growth’)).\n* Ossificans is from Latin ossīs (a plural form of ossum (“bone”), ultimately from Proto-Indo-European *h₃ésth₁ (“bone”)) + -ficāns (the present active participle of -ficō (suffix forming chiefly causative or factitive verbs)).\n* Prōgressīvā is the ablative feminine singular of prōgressīvus (“progressive”), from prōgressus (“advanced, proceeded; developed, progressed”) (the perfect active participle of prōgredior (“to advance, proceed; (figurative) to develop, progress”), from prō- (prefix denoting a forward direction) + gradior (“to step; to walk; to advance”) (ultimately from Proto-Indo-European *gʰredʰ- (“to go; to walk”))) + -īvus (suffix forming adjectives).\nThe disease was originally termed myositis ossificans progressiva in 1868. The use of fibrodysplasia in place of myositis was suggested by K. H. Bauer and W. Bode in 1940, and adopted by the American medical geneticist Victor A. McKusick (1921–2008) in his work Heritable Disorders of Connective Tissue (1956).",
  "head_templates": [
    {
      "args": {
        "1": "-",
        "head": "fibrodysplasia ossificans progressiva"
      },
      "expansion": "fibrodysplasia ossificans progressiva (uncountable)",
      "name": "en-noun"
    }
  ],
  "hyphenation": [
    "fi‧bro‧dys‧plas‧ia"
  ],
  "lang": "English",
  "lang_code": "en",
  "pos": "noun",
  "senses": [
    {
      "categories": [
        "English entries with incorrect language header",
        "English lemmas",
        "English multiword terms",
        "English nouns",
        "English terms borrowed from Latin",
        "English terms borrowed from New Latin",
        "English terms derived from Latin",
        "English terms derived from New Latin",
        "English terms derived from Proto-Indo-European",
        "English terms derived from the Proto-Indo-European root *-wós",
        "English terms derived from the Proto-Indo-European root *bʰeyd-",
        "English terms derived from the Proto-Indo-European root *dus-",
        "English terms derived from the Proto-Indo-European root *dʰeh₁-",
        "English terms derived from the Proto-Indo-European root *gʰredʰ-",
        "English terms derived from the Proto-Indo-European root *pro-",
        "English terms derived from the Proto-Indo-European word *h₃ésth₁",
        "English terms with IPA pronunciation",
        "English terms with audio links",
        "English terms with quotations",
        "English uncountable nouns",
        "Requests for gender in Arabic entries",
        "Requests for gender in Czech entries",
        "Requests for gender in Dutch entries",
        "Requests for gender in Hebrew entries",
        "Requests for gender in Latvian entries",
        "Requests for gender in Limburgish entries",
        "en:Genetic disorders"
      ],
      "examples": [
        {
          "ref": "1956, Victor A[lmon] McKusick, “Concluding Comments”, in Heritable Disorders of Connective Tissue, St. Louis, Mo.: The C. V. Mosby Company, →OCLC, pages 194–195",
          "text": "The cardinal manifestations of fibrodysplasia ossificans progressiva are microdactyly and progressive ossification of fascia, [aponeuroses], and other fibrous structures related to muscles.",
          "type": "quotation"
        },
        {
          "ref": "2006 April 23, Eileen M. Shore [et al.], “A Recurrent Mutation in the BMP Type I Receptor ACVR1 Causes Inherited and Sporadic Fibrodysplasia Ossificans Progressiva”, in Nature Genetics, volume 38, New York, N.Y.: Nature Portfolio, published 1 May 2006, →DOI, →ISSN, →OCLC, abstract, page 525",
          "text": "Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. We mapped FOP to chromosome 2q23-24 by linkage analysis and identified an identical heterozygous mutation (617G → A; R206H) in the glycine-serine (GS) activation domain of ACVR1, a BMP type I receptor, in all affected individuals examined.\nThis article announced the discovery of the gene in which a mutation causes the disease.",
          "type": "quotation"
        },
        {
          "ref": "2022 July 7, Alex Pope, “Hemel Hempstead Mother’s Funding Plea for Daughter’s Rare Disease”, in BBC News, archived from the original on 2023-12-11",
          "text": "A mother of a one-year-old girl with an illness that turns muscle into bone has urged the government to do more to help research into rare conditions. Lexi Robins, of Hemel Hempstead has the very rare condition Fibrodysplasia Ossificans Progressiva (FOP).",
          "type": "quotation"
        }
      ],
      "glosses": [
        "A very rare, disabling genetic disorder of the connective tissue in which fibrous tissue (including ligaments, muscles, and tendons) ossifies (“transforms into bone”) when damaged."
      ],
      "links": [
        [
          "medical",
          "medical"
        ],
        [
          "genetics",
          "genetics"
        ],
        [
          "rare",
          "rare#Adjective"
        ],
        [
          "disabling",
          "disable#Verb"
        ],
        [
          "genetic disorder",
          "genetic disorder"
        ],
        [
          "connective tissue",
          "connective tissue"
        ],
        [
          "fibrous",
          "fibrous"
        ],
        [
          "tissue",
          "tissue#Noun"
        ],
        [
          "ligament",
          "ligament"
        ],
        [
          "muscles",
          "muscle#Noun"
        ],
        [
          "tendon",
          "tendon"
        ],
        [
          "ossifies",
          "ossify#English"
        ],
        [
          "transforms",
          "transform#Verb"
        ],
        [
          "bone",
          "bone#Noun"
        ],
        [
          "damaged",
          "damage#Verb"
        ]
      ],
      "qualifier": "medical genetics",
      "raw_glosses": [
        "(medical genetics) A very rare, disabling genetic disorder of the connective tissue in which fibrous tissue (including ligaments, muscles, and tendons) ossifies (“transforms into bone”) when damaged."
      ],
      "synonyms": [
        {
          "word": "FOP"
        },
        {
          "word": "Münchmeyer disease"
        },
        {
          "word": "myositis ossificans progressiva"
        },
        {
          "word": "stone man syndrome"
        }
      ],
      "tags": [
        "uncountable"
      ],
      "wikipedia": [
        "Harry Raymond Eastlack",
        "Julius Springer",
        "Mütter Museum",
        "Theodor von Dusch",
        "Victor A. McKusick"
      ]
    }
  ],
  "sounds": [
    {
      "ipa": "/ˌfaɪbɹəʊdɪsˈpleɪzɪə ɒˈsɪfɪkɑːnz pɹəˈɡɹɛsɪvə/",
      "tags": [
        "Received-Pronunciation"
      ]
    },
    {
      "ipa": "/-ˈpleɪʒə-/",
      "tags": [
        "Received-Pronunciation"
      ]
    },
    {
      "ipa": "/ˌfaɪbɹoʊdɪsˈpleɪʒ(i)ə ɒˈsɪfɪkænz pɹəˈɡɹɛsɪvə/",
      "tags": [
        "General-American"
      ]
    },
    {
      "ipa": "/-ˈpleɪziə-/",
      "tags": [
        "General-American"
      ]
    },
    {
      "ipa": "/-pɹoʊ-/",
      "tags": [
        "General-American"
      ]
    },
    {
      "audio": "En-us-fibrodysplasia ossificans progressiva.oga",
      "mp3_url": "https://upload.wikimedia.org/wikipedia/commons/transcoded/b/b3/En-us-fibrodysplasia_ossificans_progressiva.oga/En-us-fibrodysplasia_ossificans_progressiva.oga.mp3",
      "ogg_url": "https://upload.wikimedia.org/wikipedia/commons/b/b3/En-us-fibrodysplasia_ossificans_progressiva.oga",
      "tags": [
        "General-American"
      ],
      "text": "Audio (GA)"
    }
  ],
  "translations": [
    {
      "code": "ar",
      "lang": "Arabic",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "خلل التنسج الليفي المعظم المترقي"
    },
    {
      "code": "eu",
      "lang": "Basque",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "feminine"
      ],
      "word": "fibrodisplasia osifikatzaile progresibo"
    },
    {
      "code": "ca",
      "lang": "Catalan",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "feminine"
      ],
      "word": "fibrodisplàsia ossificant progressiva"
    },
    {
      "code": "cmn",
      "lang": "Chinese Mandarin",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "進行性骨化性纖維發育不良"
    },
    {
      "code": "cmn",
      "lang": "Chinese Mandarin",
      "roman": "jìnxíngxìnggǔhuàxìngxiānwéifāyùbùliáng",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "进行性骨化性纤维发育不良"
    },
    {
      "code": "cs",
      "lang": "Czech",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "fibrodysplasia ossificans progressiva"
    },
    {
      "code": "nl",
      "lang": "Dutch",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "fibrodysplasia ossificans progressiva"
    },
    {
      "code": "eo",
      "lang": "Esperanto",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "progresa ostiĝa fibrodisplazio"
    },
    {
      "code": "fi",
      "lang": "Finnish",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "fibrodysplasia ossificans progressiva"
    },
    {
      "code": "fr",
      "lang": "French",
      "note": "fibrodysplasie ossifiante progressive f",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged"
    },
    {
      "code": "de",
      "lang": "German",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "feminine"
      ],
      "word": "Fibrodysplasia ossificans progressiva"
    },
    {
      "code": "he",
      "lang": "Hebrew",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "תסמונת FOP"
    },
    {
      "code": "it",
      "lang": "Italian",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "feminine"
      ],
      "word": "fibrodisplasia ossificante progressiva"
    },
    {
      "alt": "しんこうせい こつかせい せんいいけいせいしょう",
      "code": "ja",
      "lang": "Japanese",
      "roman": "shin kōsei kotsu ka sei sen ī kei seishou",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "進行性骨化性線維異形成症"
    },
    {
      "alt": "進行性骨化性纖維異形成症",
      "code": "ko",
      "lang": "Korean",
      "roman": "jinhaengseong golhwaseong seomyuihyeongseongjeung",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "진행성 골화성 섬유이형성증"
    },
    {
      "code": "lv",
      "lang": "Latvian",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "progresējošā osificējošā fibrodisplāzija"
    },
    {
      "code": "li",
      "lang": "Limburgish",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "fibrodysplasia ossificans progressiva"
    },
    {
      "code": "mk",
      "lang": "Macedonian",
      "roman": "progresivna osifiračka fibrodisplazija",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "прогресивна осифирачка фибродисплазија"
    },
    {
      "code": "ml",
      "lang": "Malayalam",
      "roman": "phaibrōḍisplāsiya ōsiphikkaṉsŭ prōgressiva",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "ഫൈബ്രോഡിസ്പ്ലാസിയ ഓസിഫിക്കൻസ് പ്രോഗ്രെസ്സിവ"
    },
    {
      "code": "fa",
      "lang": "Persian",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "فیبرودیسپلازی استخوانیشونده پیشرونده"
    },
    {
      "code": "pl",
      "lang": "Polish",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "neuter"
      ],
      "word": "postępujące kostniejące zapalenie mięśni"
    },
    {
      "code": "pt",
      "lang": "Portuguese",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "feminine"
      ],
      "word": "fibrodisplasia ossificante progressiva"
    },
    {
      "code": "ro",
      "lang": "Romanian",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "feminine"
      ],
      "word": "fibrodisplazie osificantă progresivă"
    },
    {
      "code": "ru",
      "lang": "Russian",
      "roman": "fibrodisplazíja ossificírujuščaja progressírujuščaja",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "feminine"
      ],
      "word": "фибродисплази́я оссифици́рующая прогресси́рующая"
    },
    {
      "code": "es",
      "lang": "Spanish",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "tags": [
        "feminine"
      ],
      "word": "fibrodisplasia osificante progresiva"
    },
    {
      "code": "tr",
      "lang": "Turkish",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "fibrodisplazi ossifikans progressiva"
    },
    {
      "code": "vi",
      "lang": "Vietnamese",
      "sense": "genetic disorder in which fibrous tissue ossifies when damaged",
      "word": "hội chứng người hoá đá"
    }
  ],
  "word": "fibrodysplasia ossificans progressiva"
}

This page is a part of the kaikki.org machine-readable All languages combined dictionary. This dictionary is based on structured data extracted on 2024-06-04 from the enwiktionary dump dated 2024-05-02 using wiktextract (e9e0a99 and db5a844). The data shown on this site has been post-processed and various details (e.g., extra categories) removed, some information disambiguated, and additional data merged from other sources. See the raw data download page for the unprocessed wiktextract data.

If you use this data in academic research, please cite Tatu Ylonen: Wiktextract: Wiktionary as Machine-Readable Structured Data, Proceedings of the 13th Conference on Language Resources and Evaluation (LREC), pp. 1317-1325, Marseille, 20-25 June 2022. Linking to the relevant page(s) under https://kaikki.org would also be greatly appreciated.